Topical problems of hunter NLS diagnostics,metatron nls parts 3
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In 1975 R. Monroe patented the method of potentiation of paranormal
state of the human brain at the expense of stereo sounds being entered into
the right and left ear of a probationer with the difference of 4?7 Hz.
For increment of effect of supersensitive perception R.Richards and
J.Ruddle (Oxford University) offered to use a weak alternating magnetic field
resonant to theta?rhythm of the brain in combination with photic and sound
stimuli. In the opinion of Prof. Rudolph Kapelner (Neurological Institute of
Vienna University), excited by magneto?light?acoustic impulse cerebral
hemispheres “become a source of new?type mentality and new knowledge”.
None other than Nobel Prize winner in physics Danny Gabor, the dis?
coverer of principle of holography, made an interesting conclusion that ultra?
weak photon emission observable with all animals and plant organisms exam?
ined, sharply increases when the biological system starts dying (regardless of
death type — whether as a result of, e.g. mechanical destruction, intoxica?
tion, overheating or freezing). Performed in parallel parapsychological
researches (Right test) have shown significant increase of test effectiveness
with probationers.
Dr. Siros Murphy, who has performed his studies of supersensitive per?
ception in mental and cancer hospitals, states that high paranormal abilities
were discovered both among patients of the hospitals and their medical staff.
Unique researches performed by Prof. Henry Abarbanel (Institute of
Nonlinear Science, San Diego) in San Diego federal prison during death
51 50
discovered previously unknown Greek colony established approximately in
1800 B.C. at the hill Assiros?Tiumba in Asia Minor.
The latest developments of HGY Inc. firm in the area of computer super?
sensory medical diagnostics systems merit a special attention. Computerized
tomographic systems and ultrasound scanners show stereoscopic picture of
internals in any perspective required. Reference color imposed on the picture
allows a doctor to intuitively determine areas of dyscrasia at the body’s pro?
jection.
Each of these achievements is a result of long?term researches and signif?
icant efforts of developers and manufactures of such equipment. They all
widely demonstrate unlimited abilities of systems of nonlinear analysis,
search and forecast.
nauts performed tests of the “Ariel” system aimed for emergency communi?
cation with the Earth is case of disabled radio communication or other emer?
gency situations. The US Navy also tries to use similar equipment called
“Umbriel” for communication with submarine crews.
This equipment is already out of military care. After the veil of secrecy was
lifted from such equipment large group of devices called as “brain machines”
becoming very popular in the USA, Japan and Western Europe was created.
The “Boeing” company has been already using systems of nonlinear con?
trol in aircraft construction very intensively. The computer that controls
assembling projects images of separate units and details to monitor. The sys?
tem of nonlinear control will report information on defective units in the
most natural intuitive form.
“We need an advanced technology to fundamentally change methods of
designing and manufacture. We consider “brain machines” as an obvious next
step”. (G. Hobbit, president of Воеing Тесhпо1оgу Services).
The same Boeing has developed extremely original system for testing new
aircraft models. Developers vary details of construction and with the help of
nonlinear analysis obtain proper information on “weak points” in yet unbuilt
aircraft.
Californian VPL?Research Company has developed and is continuously
improving the most complicated procedure that allows obtaining three?
dimensional graphic presentation of abstract massifs illustrating multifactor
intuitive forecast of financial situations. The computer program simulates
different probable extreme cases, while probability of their occurrence and
credibility value of the forecast are being estimated with the help of systems
of nonlinear analysis. According to postulates of entropy logic, situations of
danger, risk or catastrophe are easily detectable in model experiments with
the use of systems of nonlinear forecast.
In any case practical application of “brain machines” for prediction of
development of situations and making decisions under deficit of initial infor?
mation results in additional profit to companies using such equipment.
The developer of very successful designs of “brain machines” is the pro?
fessor in psychology of Vienna University, specialist in electronics Rudolph
Kapelner.
Thus, with the help of “AGM?Меdium 12/60” device developed by АGМ
Соrроrаtiоn company (Linz, Austria) in collaboration with Vienna
University a large accident at the nuclear power plant in Norway was suc?
cessfully prevented.
Experience of using “brain machines” in archeology is very interesting.
With the help of device of the same АGМ Соrp. Dr. Solomon Poppelarous
53 52
Nowadays it is hard to fully estimate consequences of creation of psy?
chotron weapon. A country first making decisive breakthrough in this area
will obtain such superiority over its potential enemies that can be compared
with monopolistic possession of nuclear weapon only.
Although conclusions of the given study are not a step forward in estima?
tion of the program aimed to provision of the US long?term superiority in
researches in the area of PAS announced by G. Bush, the study is of signifi?
cant interest due to fundamental, comprehensive character of the work.
This fact gives to estimates and conclusions of the APS a special weight,
which, seemingly, previous works of the same type were short of.
This explains the reaction manifested by opponents of PAS development
upon publication of the given study. Its appearance once again exacerbated
debates on the matter in the Congress. But in general, main conclusions of
the APS study were not prejudiced during disputes, and this fact is of very
importance. It could be said that publication of the given report and its cen?
tral conclusions virtually exhausted debates on scientific and technical
aspects of the PAS creation program, and ultimately made clear positions of
the most authoritative in the given matter American scientists.
And what are the conclusions of the commission? In comparison with the
report’s volume (639 pages) they are very laconic. Let us quote from the very
report:
“In the recent years gigantic steps in development of psychotron arms sys?
tems were made. In this connection new alluring opportunities to obtain
inaccessible information by using psychotron devices as well as methods of
telekinetic influence on technical systems with the purpose of their distant
destruction appear.
A 3?4?year program of military application studies performed by organi?
zations co?executors by order of the U.S Department of Defense is taking
shape. The ultimate goal of this program is assured application of PAS in
solving applied problems of the state defense.
At the same time the study group still sees significant problems in scien?
tific and technical comprehension of many matters in this area. Successful
solving of these problems plays a key role in achievement of technical char?
acteristics required for creation of effective system of psychotechnological
weapon.
Characteristics of the most important PAS components shall be improved
by several orders of the value. As these components are interrelated with each
other their improvements shall be mutually coordinated. Decision of impor?
tant matters related to integration of the PAS with already existing weapon
systems in general also substantially depends on information, which is lack?
PSYCHOTRON WEAPON ?
NEW STRATEGIC DIRECTION OF
DEVELOPMENT OF ARMS SYSTEM
OF THE U.S. ARMED FORCES.
Members of the commission of the American Physical Society * resumes con?
clusion of the commission on possibilities of creation of psychotron weapon and
decision of the U.S. Government to deploy such weapon.
BY C. PATEL, Т. JOHNSON, E. KRICK
In January of 1996 the American Physical Society started studying the
state of development of psychotron arms systems in the USA. The results of
the study published just at the end of February 1998 represent extensive esti?
mate of possibilities to use such weapon for tasks related to matters of the
country defense.
The commission consisted of 21 members (the authors were its members
as well) set itself an object to prepare a report to be technical basis for creation
of deployed network of psychophysical weapon according to plans of sup?
porters of using psychotron systems for solving applied defense problems.
The commission was composed of specialists in different areas of science
and technology playing an important role in development of psychotron
weapon.
They represent wide spectrum of scientific and industrial laboratories,
many of which directly relates to creation of psychotron weapon and auxil?
iaries.
During the study we had access to secret information. Publication of the
present report was delayed for seven months during which it had been being
examined by DOD officers. As a result of such examination the report was
reduced by more than one third.
In general published results confirmed previous estimates of some leading
American scientists that at the present stage psychophysical arms systems
(PAS) can be used for meeting wide range of military challenges.
The commission has concluded that PAS can be used for creation of
principally new means and methods of prosecution of war, including creation
of new?type strategic weapon.
Creation of the physical theory of psi?phenomena by T.van Hoven was a
condition of significant progress in development of the given type of weapon.
Editor’s note: *American Physical Society (APS) is one of the largest and most authoritative American organiza?
tions uniting leading physicians of the USA, including many Nobel Prize winners.
55 54
Among other problems meant, but did not considered are level of expenses,
control over arms and strategic balance, as well as matters of home and foreign
policy related thereto. Research group of the American Physical Society that had
prepared the report “Scientific and technical aspects of development of psy?
chotron arms systems”:
N.Blumbergen, АТ & Т Bell Laboratories.
C.Patel, Harvard University.
P. Avisonis, USAF Arms Laboratory.
R.Clem, Sandia National laboratory.
А. Geriberg, Washington University.
Т. Johnson, US Military Academy.
Т. Marshall, Columbia University.
W. Morrow, Lincoln Laboratory.
А. Holecome, Mancind Unlimited Inc.
E. Vitchinsky, Cornell University.
E. Sessler, Lawrence Laboratory, Berkley.
G. Sallivan, Illinois State University.
G. Vayant, Arizona University.
E. Yariv, California Institute of Technology.
Т. Dressler, HGY Inc.
R. Zeir, Stanford University.
E.Krick, International Stanford Research Institute.
R. Jan, Princeton University.
R. Morris, Syracuse University.
А. Feyber, VPL Research.
S. Brown, J&J Inc.
The research has a long history. The decision on creation of the research
group was made by the American Physical Society on January 20, 1996; the
group was created in May 1996. Preparation of the report took 21 months (as
Patel said, “elephant gestation”); it was published on February 24, 1998. Within
seven months the report has been being examined in the US Department of
Defense as to secret information contained therein.
ing still, as we know”. The commission subjected many essential aspects of
the PAS relating to systems of management, control, communication and
reconnaissance.
Already existing psychotechnological systems give satisfactory results in
distant reconnaissance; upon organization of communication with important
distant objects, namely: submarines, aircrafts, spacecrafts etc.
Electrical screening of the given equipment, placing of the later in the
Faraday chamber, in a spacecraft or a submarine does not impede high?qual?
ity control of the distant model.
The other area of application of this equipment is forecasting and model?
ing of results of military operations and political actions, intuitive decision of
analytical tasks, choosing one of several possible outcomes in absence of any
initial information. Patterns of successful application of the PAS in creation
of space?time distant system of prevention of accidents and catastrophes are
also available. The equipment allows making forecasts on some sections: nat?
ural disasters; wars and international conflicts; air and marine catastrophes;
civil unrest etc.
Other important subject of our study is possibility to use the PAS for the
purpose of destruction of living organisms or electronic physical objects (so
called “magic weapon”).
It is certainly important for the U.S. Army to know whether such devices
are able to influence on people and to disable machinery and weapon at the
distance of thousands of kilometers.
Of all types of devices presumably able to serve the given purposes and
currently being at the development stage the most interesting one is low?fre?
quency quantum resonance Krick oscillator, which refers to the most
approved systems. Experiments with the Krick oscillator (the oscillator and
the recipient were divided by 1.5 through 30 miles between them) confirmed
possibility of distant influence on complex electronic devices and higher psy?
chic functions of living organisms.
As high?quality radiation beam is free of distortion, has minor divergence
angle and is not absorbed or dispersed by atmosphere, it is possible to place
the Krick oscillator at a space platform. In spite of so high characteristics of
the beam, possibility to use the Krick oscillator as effective weapon for dis?
abling machinery and armament and direct attack on troops in the first place
depends on experimental verification of several physical ideas so far being
considered only theoretically. If to look at this problem from the technical
positions, then the mentioned obstacles can be insuperable. Events that can
occur around these experiments in the nearest future will directly relate to the
matters of creation of strategic weapon of new type.
57 56
dulum etc. (Mizun Y.G. Biopathogenic zones — threat of disease. ?
Мoscow, 1993). A method of “rod detection” that lies in fact that such acces?
sory as, for example, a twig of hazel?tree or willow, deviates or rotates in
hands of some people coming over water?bearing, ore deposit or other abnor?
mal zones. (Malakhov А.А. Along with the rod for minerals. ? Questions and
answers, 1973, No.3).
According to some researchers this ability is inherent to from 15 to 95%
of people researched. Nevertheless, good results can be obtained by gifted
biolocation operators after long?term painstaking training only. (Sochevanov
N.N., Matveev V.S. Biophysical method in geological studies. ? Geology of
ore deposits. 1974, vol. 16,No.5; Bakirov А.G. Geological capabilities of bio?
physical method. ? Collection of reports of the conference on psychotronic
studies. Vol.1., Prague, 1973; Bondarev B.V. Biophysical effect and its appli?
cation in exploration activity. ? Scientific works of Tashkent State University,
1970, issue No. 372).
There is no equipment and methods increasing reliability of output of
biolocation operators. This fact impedes broad application of biolocation
testing nowadays.
It is highlighted in guides on rod detection that in order to get maximum
reliability of prospecting works the tree twig used as accessory shall be newly?
cut (Lomonosov М.V. About prospecting forks. ? First foundations of metal?
lurgy and ore craft. ? 1763; Blaumang М. Why does the fork rotate? ?
Science and engineering, 1975, No.1; Morish Y.I., Turobov B.V. Rod detec?
tion without mysticism. ? Nature, 1986, No.11).
The authors became interested in this claim and rod tests performed
allowed to formulate working hypothesis that synchronized interaction of the
biolocation operator with any actively functioning biological system or com?
ponents thereof exposed to intensive destruction significantly increases relia?
bility of biolocation studies. Percentage of increased reliability depends on
intuitive abilities of the operator and level of biological organization of dying
system or functional importance of used components thereof.
The authors analyzed historical data on appearance of “prophets” in the
years of social or geophysical shocks, ritual features of sacrifices, shamanism
and witchcraft from the positions of the theory of entropy logic by Theodore
van Hoven.
The is a method of increasing working capacity of operators of aviation
description and a device for its realization by influencing with series of
mechanical stimuli with the help of needles on reflexogenic zones of the skin
of breast, back, abdomen, hips and shoulders (author’s certificate of the
USSR No.738226, А 61 No.1/32, 1981).
(19) RU (11) 2119806 (13) C1
(51) 6 А 61 N 2/04
RUSSIAN AGENCY
ON PATENTS AND TRADEMARKS
(12) DESCRIPTION OF THE INVENTION
to the patent of the Russian Federation
(21) 96117021/14 (22) 21.08.96
(46) 10.10.98 Bulletin No. 28
(72) Nesterov V.I., But Y.S.
(71) (73) Nesterov Vladimir Igorevich,
But Yury Stanislavovich
(54) METHOD OF INCREASING RELIABILITY
OF BIOLOCATION STUDIES
(57) Method of increasing reliability of biolocation studies refers to med?
icine, namely to labour physiology. The invention allows to increase degree
of reliability of output of biolocation operators by impulse low?frequency
unipolar magnetic field with adjustable values under condition of selection of
characteristics of actuating magnetic field by the biolocation operator itself,
provided that a biological object (an organism, a system of organisms) or its
components (organs, tissues, cell elements, including blood and sperm) in
the phase of irreversible changes (death) acting as initiator of the operator’s
intuitive abilities is placed between field source and temporal region of the
operator. Using of biological initiators of high?level specific and biological
organization actively functioning before starting of the initial phase of
destruction with the application of methods of destruction of biological ini?
tiators with rough prolonged phases of final death thereof is possible. Formed
by a generator magnetic impulses influence on both hemispheres of the brain
of the biololocation operator synchronously with influence of factors causing
irreversible destructions to the biological object used as initiator of intuitive
abilities of the biolocation operator leading to its death.
The invention refers to medicine, namely to labour physiology, and can be
used by biolocation operators for increasing reliability of biolocation studies
being performed. Biolocation studies are performed with the application of
special indicators (accessories) ? bifurcated tree twig, Г?shaped frame, pen?
59 58
heating, undercooling or intoxication) at the moment of its death the biolog?
ical object rapidly increases emission of photons, whether it is animal or plant
organism (Parapsychology: Study course of Munich Institute of
Parapsychology. Moscow, 1992).
Formed by a generator magnetic impulses influence on both hemispheres
of the brain of the biololocation operator synchronously with influence of
factors causing irreversible destructions to the biological object used as initia?
tor of intuitive abilities of the biolocation operator leading to its death.
The essence of the invention lies in the following. The probationer tested
as biolocation operator preliminarily selects optimal values of parameters of
magnetic impulses causing maximum influence on him formed by inductors:
polarity of magnetic field for right and left hemispheres, values of carrier fre?
quency, magnetic induction, interruption frequency and porosity of generat?
ed unipolar magnetic impulses filled by current of carrier frequency.
For the purpose of oblective control over the value of reliability of output
as biolocation operator the probationer was offered to guess one of three or
five Zener cards containing different geometrical figures (square, triangle,
cross, circle and two parallel lines).
Each card was previously placed to the envelope made of heavyweight
opaque paper and then the envelopes were mixed in absence of probationers.
This method is also known as the Right test.
Then the biological object used as biological initiator (solitary microor?
ganisms or their colonies, different plants and animals) or parts thereof (bio?
logical liquids, cell elements and their homogenates) was placed between
temporal region of the probationer’s head and one of the magnetic inductors.
The biological object shall be functionally active, but in the initial phase of
irreversible destructions, that are inevitably shall end by its death.
The authors used already known influence factors leading to destruction
and death of biological objects: mechanical injury, including decapitation
and models of blood?letting, freezing, intoxication, multiple burns (thermal
and acid ones), starvation, dehydration, hypoxia and asphyxia, influence by
electric current, hard ionizing radiation and some own methods such as, for
example, influence by laser beam.
Main test and statistic processing of the results obtained were performed
against the background of artificially triggered destruction and death of the
biological object or system used.
The essence of the invention is proved by the following examples.
A group of probationers (n = 12) was offered to perform the Right test in
order to provide objective control over reliability of their work as biolocation
operators, i.e. to determine one of five Zener cards containing different geo?
The given technical decision is not acceptable for biolocation operators
due to peculiarities of their workplace, special equipment and operating algo?
rithm. Besides, the prototype device does not allow to adjust degree of influ?
ence of mechanical stimuli on the organism of certain operator and does not
exclude traumatism of cutaneous coverings.
There is a method of increasing working capacity of an operator of avia?
tion description by affixing to the skin of back and hips electrodes connected
to the generator of electrical impulses regulated by individually selected fre?
quency and amplitude. Two working modes are possible: periodical engaging
of stimulation upon sleepiness and muscular discomfort or constantly in the
working process (Russian patent No. 2,006,234 С1, class А 61 No.1/32).
The is a method of prophylaxis of peoples’ overfatigue and increasing their
working capacity by deepening and increasing time of natural sleep at the
expense of influence of electromagnetic oscillations on the brain in the form
of impulse signals adjustable by form, frequency, duration, porosity and
amplitude (author’s certificate of the USSR No. 700140, class А 61 No.1/32,
30.11.79, the U.S. Patents No. 3,989,051, 4,334,525 dated 15.06.82, No.
4,383,522 dated 17.05.83 ? “Lenar”?type devices).
The closest to the claimed one is the method of influence of pulse current
on central nervous system (author’s certificate of the USSR No. 904,720,
class А 61 No. 1/34, 15.02.82, author E.М. Kastrubin) through four elec?
trodes affixed to the skin of the frontal forehead and mastoid region.
The main drawback of the above prototypes is subjective setting of work?
ing mode by selecting strength of actuating current basing on unpleasant feel?
ings of the specific probationer in the points of affixing of electrodes.
As a result of analysis of engineering level it was established that the task
of increasing reliability of biolocation studies by using any physical factors
has not been being solved yet.
The goal of the invention is to develop a method increasing reliability of
output of biolocation operators by more than 80%.
The goal set is achieved by influence on both hemispheres of the brain of
the biolocation operator by impulse low?frequency unipolar magnetic field
with adjustable parameters under condition of selection of characteristics of
actuating magnetic field by the biolocation operator itself, provided that a
biological object (an organism, a system of organisms) or its components
(organs, tissues, cell elements, including blood and sperm) in the phase of
irreversible changes (death) acting as initiator of the operator’s intuitive abil?
ities is placed between field source and temporal region of the operator.
The method is based on discovery of the Nobel prize winner in physics
Danny Gabor that regardless of type of death (mechanical destruction, over?
61 60
Academy (head of the chair professor, corresponding member of Academy of
Medical?Technical Sciences doctor of medical?technical sciences Elomenko
S.N.).
The highest results — 84.82+/?8.14% (in control experiment, upon using
live animal ?66.48+/?7.71%) ? were obtained during the experiment with
rhesus monkey provided by a representative of HGY Company in Omsk
financing studies of the authors.
The Right test without using biological objects as initiators made up
50.07+/?12.34% in average.
Upon analysis of results obtained the authors paid their attention to the
fact that the Right test was in all cases higher with operators directly per?
forming decapitation, upon slaughter of young actively functioning and
healthy animals and depended on level of specific organization of the biolog?
ical object used.
The Right test was maximum effective upon synchronization of the biolo?
cation operator’s work with influence of factors of destruction of biological
system, i.e. upon using just slaughtered animals. Then the results have been
gradually decreasing and rapidly declined in 1.5?2.5 days (with different
species) provided that corpses were kept under indoor temperature.
The authors concurrently performed researches on studying possibilities
of application of different organs, tissues and cell embryos taken from human
and animal bodies, as well as tissues of embryos (fetal tissues after abortion)
and newborns died in childbed or within first hours or days after the birth.
Animals were used as slaughtered and died as a result of modeling of fatal
disease (peritonitis) or intoxication (overdose of narcosis) ones. Analogous
researches were performed with organs taken from bodies of people died as a
result of crash, accident, murder or suicide, as well as a result of serious
incurable disease (oncopathology).
This part of work was performed on the base of pathologoanatomic build?
ing of Omsk Medicine Academy conjointly with employees of chairs of
pathological anatomy and forensic medicine under control of the city depart?
ment of Internal Affairs and Federal Security Service.
The lowest results were obtained upon work with bone tissue as biological
initiator, the highest ones — with blood, cardiac and brain tissues.
As an example results of the Right test obtained upon using different tis?
sues of rhesus monkey as initiator can be cited: bone tissue — 54.47+/?
11.18%, muscular tissue — 56.34+/?12.31%, skin and hair — 67.13+/?
12.59%, liver tissue — 67.84+/?12.64%, testicles — 74.69+/?18.35%, blood
— 78.43+/?18.49%, cardiac tissue — 80.21+/?19.17% and, finally, brain tis?
sue — 82.93+/?20.12%. The results turned out to be higher upon work with
metrical figures (square, triangle, cross, circle and two parallel lines). Each
card was previously placed to the envelope made of heavyweight opaque
paper and then the envelopes were mixed in absence of probationers.
Upon control determination of Zener cards the biolocation operator pre?
liminarily selected optimal values of parameters of magnetic impulses formed
by inductors causing maximum influence on him by deviation angle of Г?
shaped biolocation frame. Then Petri dish with Escherichia coli culture of
microorganisms in the nutrient medium was placed between temporal region
of the probationer’s head and one of the magnetic inductors. Then Petri dish
was filled by 10 ml of 1% phenol solution as antiseptic. The main study was
performed in 5 (five) minutes after beginning of sterilization against the back?
ground of mass death of solitary specimens and all colony of microorganisms
used. When using this method the quantity of reliable information made up
68.4+/?6.18% under mathematical expectation of 20%. Control studies
showed 51.34+/?10.27% accordingly under the same mathematical expecta?
tion of 20%. Probability of accidental obtaining of this result turned out to be
less than 0.05. In the next series of tests decapitation of laboratory animals
(white mice, rats, guinea?pigs and dogs) was performed.
For decapitation of animals the authors constructed special guillotine
which design philosophy is the subject of own invention.
Carcasses of agonizing animals and their cut?off heads were placed
between one of the magnetic inductors and the head of the operator and then
the Right test was performed. Control studies, when live animals were placed
between inductor of magnetic field and operator in comparison with the ini?
tial control test — without using a biological object as biological initiator of
abilities of the biolocation operator — were performed preliminarily.
When using this method the quantity of reliable information made up as
follows:
Upon slaughter of white mice: 69.22+/?6.31% (in control experiment,
upon using live animals — 52.16+/?9.26%),
Upon using white rats: 80.14+/?6.42% (in control experiment, upon
using live animals — 64.53+/?8.17%),
Guinea?pigs: 69.89+/?8.41% (in control experiment, upon using live ani?
mals — 55.34+/?7.13%),
Rabbits: 76.18+/?7.64% (in control experiment, upon using live animals
— 56.45+/?8.06%),
Dogs: 82.64+/?7.88% (in control experiment, upon using live animals —
67.13+/?8.32%).
Experimental part of the work was performed in the laboratories of the
chair of topographical anatomy and operative surgery of Omsk Medicine
63 62
sis of lifetime of the patients tested (cancer of stomach, breast, head of pan?
creas, uterus and lungs). These researches were performed in patholo?
goanatomic building of Omsk Medicine Academy by lecturer of the chair of
topographical anatomy and operative surgery But Y.S.
Obtained increasing of reliability of biolocation studies using the claimed
method allowed authors to successfully test it upon guessing winning num?
bers of cash and prize lotteries. Number of winnings in the group of proba?
tioners subjected to influence of magnetic field in the presence of a biologi?
cal initiator (corpse material) was 3.7 times higher than in control group.
FORMULA OF THE INVENTION
1. Method of increasing reliability of biolocation studies by influence on
both hemispheres of the brain of the biolocation operator by impulse low?fre?
quency unipolar magnetic field with parameters adjustable by the operator
himself, provided that between one of field sources and temporal region of
the operator the biological indicator of his intuitive abilities in the form of a
biological system, biological object or components thereof in the initial phase
of irreversible changes, inevitably ended by destruction and death of the used
biological initiator, is placed; and the work of the biolocation operator shall
be synchronized with the moment of maximum destruction of biological ini?
tiator.
2. Method as in clause 1 differing by selection of biological initiators of
high?level specific and biological organization actively functioning before
start of the initial phase of destruction and by using methods of destruction
of biological initiators with rough prolonged phases of their final death.
fetal tissues, an organ’s homogenate washed by concentrated sulphuric acid
or placed under laser beam or between carbon electrodes periodically gener?
ating electric corona dischage synchronically with the work of the magnetic
inductor and the biolocation operator rather than entire organ.
The highest result of the Right test was obtained upon work with the
corpse of Mr. S., 36 years old. His death occurred as a result of multiple gun?
shot wounds in the area of abdomen and lower extremities from loss of criti?
cal volume of blood. In 9 (nine) hours after the death the Right test made up
96.42+/?12.34%, in a day its effectiveness decreased to 88.34+/?11.24%, in
three days — up to 74.82+/?10.18%.
Upon work with the corpse of Mrs. Y., 76 years old pensioner, died from
multiple metastases to mesenteric lymph nodes against the background of
high?grade cachexia, with the clinical diagnosis of IV?degree cancer of stom?
ach, the Right test performed in 4 (four) hours after the death made up
79.47+/?10.21%, in a day — 71.13+/?9.97%, in three days — 56.39+/?
8.75%.
Finally, possibility of using patients with serious chronic (cancer) brain
diseases was evaluated.
Thus, with patient N., 49 years old with the diagnosis of IV?degree cere?
brum medulloblastoma (died in 9 weeks after research) the Right test made
up 79.13+/?10.17%.
Upon work with patient C., 54 years old (diagnosis: extracerebral tumor
of the brain) the Right test made up 72.26+/?10.11%.
Thus, the following conclusion was made. The younger and functionally
more active the biological object used as biological initiator of intuitive abil?
ities of biolocation operators the harder its destruction and death, then the
higher percentage of guessing Zener cards by probationers as biolocation
operators. Whether the biological object used as biological initiator of intu?
itive abilities of biolocation operators is functionally incomplete or has
chronic diseases or intoxications or mechanism of its death is transient, then
the lower percentage of guessing by probationers as biolocation operators.
In order to facilitate statistical processing of obtained data at the moment
of adjustment of magnetic inductors the authors have developed a special
software program. In the work the authors used a conventional generator of
magnetic impulses of “Gradient” type equipped with current breaker in the
chain of magnetic inductors modified for separate adjusting parameters of N?
S inductors and conjugated with computer control program and sound card.
The claimed method was tested by the authors during medical biolocation
diagnostics with the purpose to determine possibilities of diagnosis verifica?
tion of patients with oncopathology confirmed on surgical table and progno?
UNITED STATES PATENT 6,549,805
NESTEROV ET AL. APR. 15, 2003
TORSION DIAGNOSTIC SYSTEM
UTILIZING NONINVASIVE BIOFEEDBACK
SIGNALS BETWEEN THE OPERATOR, THE
PATIENT AND THE CENTRAL PROCESSING
AND TELEMETRY UNIT
ABSTRACT
BACKGROUND OF THE INVENTION
The present invention relates generally to a biofeedback medical diagnos?
tic system. More particularly, the system of the invention utilizes remote
noninvasive biofeedback signal between the operator, the patient, and the
CPT (central processing and telemetry) device to determine a pathological
condition of the patient. The biofeedback signal is generated subconsciously
and is based on device enhanced intuition.
A variety of medical diagnostic systems are known in the art to deter?
mine the patho?physiological status of the patient in general and to diag?
nose a variety of ailments and their state of progression. A simple example
of such a system is a visual diagnostic device based on critical fusion fre?
quency such as described in the U.S? Pat. No. 6,129,436 by Treskov or the
Russian Patents No. 339,280 and 1,076,087. In a self?administered test, the
patient can gradually increase the frequency of a blinking light until the
point of fusion is reached and the patient is unable to distinguish between
individual bursts of light. The frequency of that fusion is indicative of the
state of the patient’s nervous system and can be tracked over time to moni?
tor its changes. An improvement is described in the Russian Patent No.
814,337 wherein the test is administered before and after a physical exer?
cise. Such systems have generally limited ability to indicate the variety of
patient’s conditions due to the fact that only a part of the nervous system
responsible for processing a visual stimulus is involved with the test. Such
complex phenomenon as a change in working ability or the state of tired?
ness of a patient frequently results from other changes in the nervous sys?
tem that would go undetected by such a device.
65 64
The collection of proceedings of Institute
of Practical Psychophysics (IPP)
Volume I
Topical problems
of NLS?diagnostics
(theoretical and clinical)
Moscow – 2006
BBK
22.314 (4Ros?Moskva)
C34
The collection of proceedings of Institute of Practical Psychophysics (IPP)
“Topical problems of NLS?diagnostics (theoretical and clinical)” /Under
editorship V.I.Nesterov. — Moscow: PROSPEKT Publishing house, 2006. — 88 pages
? 5000 copies.
ISBN 5?94349?037?Х
3
CONTENTS:
Computer non?linear diagnostics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5
Clinic Tech Inc. — ascending into the XXI century . . . . . . . . . . . . . . . . . 7
Method of computer non?linear analysis and its role in diagnostics . . . . . 9
Potentials of NLS method in diagnosing gastric and calonic cancers . . . . . . 12
New potentials of NLS?method in colonic neoplasm diagnostics . . . . . 16
NLS?method in vascular pathology diagnosis . . . . . . . . . . . . . . . . . . . . . 22
NLS?diagnostics of lung abscess . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24
NLS?diagnostics of degenerative changes in the spine . . . . . . . . . . . . . . 27
NLS?diagnostics of diffuse infiltrative lung diseases . . . . . . . . . . . . . . . . 30
NLS?diagnostics of prostate diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35
NLS diagnostics of affected regional lymph nodes at a
mammary gland cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39
NLS?investigation in evaluating the condition
of knee?joint affected by osteoarthritis deformans . . . . . . . . . . . . . . . . . . 41
Potentials of NLS?investigation in the presurgical evaluation
of intramural invasion of gastric cancer . . . . . . . . . . . . . . . . . . . . . . . . . . 44
Potentials of NLS?scopy in adrenal tumor diagnostics . . . . . . . . . . . . . . 49
Diagnosing rare instances of mammary
gland diseases using NLS?investigation . . . . . . . . . . . . . . . . . . . . . . . . . . 52
Diagnostics of toxoplasmosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55
Nonlinear diagnostics of thyroid gland pathology . . . . . . . . . . . . . . . . . . 58
Nonlinear computer diagnostics and the problem of pathology
in the hepatopancreatoduodenal area . . . . . . . . . . . . . . . . . . . . . . . . . . . . 65
MECT and NLS in diagnosing myocarditis of mild or medium gravity . . . . 72
Importance of NLS?method for diagnosing timorous diseases
of the segmented intestine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 78
5
Computer non?linear diagnostics
V.I. Nesterov
The Non?linear Diagnostics Systems (NLS) have been extensively used
lately and are gaining ever growing popularity. Even in the few cases, where
the clinical symptoms look very typical the NLS diagnostics method provides
extra information about the extent of the affection and allows to consider a
prognosis. In most cases it is of vital importance for diagnostics and conse?
quently for the right choice of treatment.
In 2000 it was 20 years since Theodore Van Hoven had developed the
theory of quantum entropy logic that underlies this method. So non?linear
diagnostics appears to be the most up?to?date of all methods of the hardware?
based diagnostics. At any rate, his discovery became a significant landmark in
diagnostical medicine.
Non?linear analysis was originally employed in organic chemistry to
determine the composition of complex compounds.
Sviatoslav Pavlovich Nesterov who introduced a trigger sensor in 1988
and thus framed the concept is acceptedly considered as the originator of the
NLS?diagnostics device (metatron). Active work was immediately started to
develop and improve the NLS?diagnostical systems. Clinical testing of the
early equipment took the period from 1990 through 1995. The late 90s saw a
fast growth of commercial production of the device and a sudden surge in the
quality of the results produced.
The non?linear diagnostics method is still in its developing stage. The
diagnostical techniques are improving so fast, that the system versions have to
be updated every six months. Due to the introduction of some new devices
equipped with digital trigger sensors, the NLS?diagnostics has become not
only far more time?efficient but also quite different in terms of quality. It is
obvious that some runtime techniques, for instance three?dimensional visu?
alization of investigation results will soon become a daily practice. The vege?
tive testing is just an example of a ready implementation. The method is
employed so widely that we should rather speak about a definite range of
indications for its use than just about its popularization.
Research centers continue their quest for some new investigation meth?
ods based on the non?linear analysis systems. So far the results appear to be
quite promising.
Unlike NMR and computer tomography, the NLS?analysis does not
need strong fields. The method seems to have good prospects for metabolism
Clinic Tech Inc. — ascending
into the XXI century
D.V. Koshelenko, S.A. Letun
Head of Clinic Tech Inc. (USA)
Moscow Office
The development of a new generation of non?linear computer scanners
(metatrons) making use of multidimensional virtual imaging of the body of
interest, has allowed to substantially improve the effeciency of the NLS?
method and even expand its fields of application despite the MRT competi?
tion. The originally volumetric pattern of scanning is a distinctive feature of
the multidimensional NLS imaging. The data thus acquired are an integral
array, which facilitates reconstructing multidimensional virtual images of
anatomical structures of the body of interest. In this connection the virtual
NLS is widely used especially for angiographic investigations with a three?
dimensional reconstruction of vascular formations.
Another promissing field of application of the three?dimensional image
reconstruction based on the data acquired by means of multidimensional
NLS is the study of hollow organs with a “virtual NLS?scopy” involved. This
kind of a system was developed by Clinic Tech Inc. for their high?rate multi?
dimensional Z?series non?linear scanners, and was called Hunter. High res?
olution maintained during spiral scanning and the use of LAPP system (a sys?
tem of parallel processors with a powerful computational capability and
speed of operation) allows to implement the principle of “virtual NLS?scopy”
on a Voxel Z multimodal DICOM?compatible work station, which is the
basic system for imaging and subsequent data processing with Clinic Tech
Inc. scanners.
NLS images are made ready for visual analysis by means of the 4D
Tissue, an original company?developed method, that allows not only to
obtain virtual multidimensional images of anatomical structures but also
select a particular biological tissue of interest giving it an extra dimension,
and additionally visualize bones, soft tissues and vessels at a time.
A specific feature of representing virtual data by Hunter system is its
simultaneous vusualization of surfaces of cavatus and extramural formations
located outside the lumen of the cavity under examination (e.g. lymph nodes,
vessels). The acquired images form a natural sequence of virtual NLS shots,
while special navigation programs automatically determine the path of the
7
studies, particularly on a cellular level. The NLS?method advances along the
path not only of technical innovations but also of new applications. Some
minor surgical operations, biopsy for one, have been long monitored using
ultrasound, fluoroscopy or computer tomography. Today we have an oppor?
tunity to have biopsy monitored by NLS. By the way, many surgeons focus on
using this method to assist major surgeries.
The cost of equipment for NLS?diagnostics is still very low as compared
to some other hardware?based methods. This is supposed to promote more
extensive use of the method in countries with low living standards. Of all
methods of hardware?based diagnostics the NLS provides representations
most proximate to the pathologicoanatomic picture. This feature of the
method along with its harmlessness, promotes rapid development of the
NLS?diagnostics.
6
Method of computer non?linear analysis
and its role in diagnostics
V.D. Artyukh,
U.A. Shovkoplyas,
A.A. Gavrilov
The computer?based non?linear analysis (NLS) as a dynamic non?
invasive informative method is increasingly used to examine the status of
health affected by pathologies of different origin. The NLS can be
applied both in vivo (to acquire an NLS?spectrum of one or another part
of an organ or tissue), and in vitro (to obtain an NLS?spectrum of
extracts from tissues, biological fluids or cells); while, rather often both
approaches can be combined for a more accurate data interpretation.
The usage of NLS at a clinic requires devices producing an at least 20?30
mT eddy magnetic field. The proceedings of the latest International
Congress of Medical Doctors (2000 and 2001), that dealt with new
methods of diagnostics give evidence of a growing number of NLS?inves?
tigations used for the diagnostical purposes ? the 2000 summit heard 16
presentations on the subject, while in 2001 they were twice as many.
S.D. Tutin et al. informed of the possibility to use the NLS to diag?
nose abscesses in the encephalon. It appears, that at an abscess in the
encephalon in the NLS?spectrum, during the biochemical homeostasis
evaluation some signals from lactate and amino acids are detected, which
disappear in the course of treatment. The NLS data in vivo correlated
well with the results of abscess sample tests made by means of MRC with
a high resolution in vitro.
Using the NLS?method the dynamics of metabolic change in the
encephalon when treating epilepsy can be traced. Some data are avail?
able, that indicate a possibility to register a decline in oxidative phos?
phorylation in the lower limbs muscles with constriction of the vessels
caused by arteriosclerosis. In the course of treatment the muscle metab?
olism appears to improve. Another trend in the application of the NLS
method is detection of metabolic disturbance of phosphorergic com?
pounds at muscular atrophy related to a pathology in the musculoskele?
tal system. Some promissing prospects for myocardial infarction diagno?
sis by means of the NLS method were described by U.A. Shovkoplyas et
al., who studied the ATP exchange in the myocardium. At a myocardial
9
“virtual scanner” by center of the cavity under examination. The path of the
motion can be chosen by operator using some other settings, which allow to
detail the NLS picture by changing the view fields. A raised representation of
the cavity surface is also achievable by shaping particular artificially shaded
areas . The produced sequences of NLS shots can be easily converted into a
standard VHS video format by means of the epi?Client program and thus be
used in standard video systems, in particular for teleradiology.
The Hunter system is primarilly designed for case detection of obstruc?
tive processes in the upper respiratory passages, bulky esophageal, gastric or
colonic formations, atherosclerotic lesions of large vessels, and disorders
affecting paranasal sinuses, urinary bladder or spinal canal. The data gath?
ered by “virtual NLS?scopy” allow to pick out the optimum spot for biopsy
and define the extent of the required surgical intervention in good time.
This technique can be used both solely and as a useful linking element
between tomographic, endoscopic and NLS investigations.
The Clinic Tech Inc. latest development is its Pincers stereo tactic
manipulator integrated into a computer scanner, which is a convenient tool
for planning interventional procedures monitored by NLS. The Pincers com?
prises a controlled stereo tactic manipulator (“arm”), a flat gentry?mounted
monitor, a cable system and software. The system provides the physician with
the means of simulating and performing interventional procedures through
an interactive link between the virtual NLS and the real operational field.
8
tor the biochemical responses to treatment.
Summing up the above it can be concluded that the ever growing use
of NLS?analysis in different fields of clinical medicine, including its
combination with MRT with contrast amplification involved, increases
the efficiency and diagnostic accuracy and is indicative of a continuous
progress in the field of internal organ visualization techniques based on
the NLS?analysis phenomenon.
11
infarction its level was proven to decrease. The NLS?analysis method was
employed to study the dynamics of change in the metabolism of lipids in
the liver affected by cirrhosis. The NLS?investigation of the pancreas
affected by malignant degeneration allows to diagnose tumor progres?
sion, judge of the efficiency of radiation? or chemotherapy and also
adjust individual dosage schemes for inoperable patients.
Moreover, NLS is reported to be used to diagnose CNS disorders,
cardiovascular diseases, muscular system disorders, prostate tumors,
mammary gland tumors and in addition to monitor radiation? and
medicinal US therapies. The researchers have demonstrated the diag?
nostic importance of NLS for arteriosclerosis, apoplexy,
encephalomyelitis and vasculitis. NLS allows to estimate the phase of a
pathology and activity of the nidus, determine a relationship between
genetic characteristics, clinical symptoms and metabolic deviations in
the encephalon. NLS helps to differentiate between benign and malig?
nant tumors in the mammary gland. The studies of abnormal changes in
the prostate gland by means of NLS showed that the method allowed to
identify an incipient change in the gland tissue and pick out the appro?
priate therapy in good time.
K.A. Kvasov et al. presented some data about diagnosing prostate
diseases (including histologically confirmed benign hypertrophy and
Aden carcinoma) by combining NLS and dynamic MRT with artificial
“Magnevist” contrasting. According to the derived results, this kind of
combination allows to define the pattern of a prostate pathology and sub?
stantially increases the diagnostic accuracy. In the recent years special
attention has been focused on a study of liver metabolism by means of
NLS necessitated by a growing number of transplantations of the organ
(in Europe the annual number of liver transplantations is around 2000
and in the USA it is 10000) and due to this method’s noninvasive evalu?
ation of the liver function in the course of implantation. The results indi?
cate apropriateness of using the NLS?analysis in these cases since the
ATP level in the liver mirrors an integrated picture of cell homeostasis.
There is a close correlation between the disturbed metabolisms of phos?
phorergic compounds and the extent of liver decompensation.
Apart from diagnosing liver disorders in vivo, the NLS allows to
judge on the state of the transplanted liver in vitro by acquiring spectral
characteristics of the organ’s metazodes. This is based on a good correla?
tion between the pathological liver metabolism defined by means of NLS
and the disease prognosis. The authors would like to emphasize that NLS
allows not only to define pathological change in the liver but also moni?
10
According to the cancer register for 1999?2000, the values of gastric and
colonic cancer cases were 80.9 and 53.1 respectively per 100000 patients, and the
death rate according to the mortality statistics was 47.35 and 19.5%. According
to the conclusions of therapy?diagnosis unit, with around 70% of patients under
active dispensary observation, the pathologies of that kind are likely to be detect?
ed as often as in 0.4?0.8 % of cases. Therefore, the NLS screening would allow to
detect GC or CC in about every 150th?200th examinee.
Considering that the emergence of clinical signs is one of the incentives
for a patient to take medical advice and a reason for hardware?based exami?
nation, some clinical implications and their pattern were evaluated in the
cases of the above mentioned diseases. As followed from the results, in 720
patients affected by GC or CC the condition appeared to be symptom?free in
42% and 32% of cases respectively or there were some signs characteristic of
previous chronic digestive tract diseases. That was the case in 77% and 92%
for the 1st phase, 56% and 68% for the 2nd phase, 23% and 32% for the 3rd
phase, and 8% for the 4th phase of the disease. The clinical implications at a
gastric cancer were of a pain?dyspepsia syndrome nature typical for the lesion
in the upper section of the digestive tract. At a colonic cancer subgroups were
segregated with dominating signs of intestinal hemorrhage, disturbed evacu?
ation or abdominal pain. A certain interrelationship was proven between the
pattern of the clinical implications and the process localization. In more than
50% of cases the clinical implications lasted less than 3 months and in 26%
of patients the CC developed acutely within a few days. It should be noted
that the so?called “minor sign syndrome” corresponded to some later phases
of the disease. The same was true for lab examination data where the change
became evident during phases III and IV (2).
The results of NLS?diagnostics for the initial phases of gastric cancer in
a series of 104 examinations showed that in 72% of cases the physician on the
assumption of a spectral similarity to the reference standard, regarded the
lesion as benign and indicative of focal mucosa hyperplasia, polyp, an area of
local inflammation, wall deformation or a small ulcer. The probability for
detecting signs of malignant change found out in the elimination mode was
under 1%. Of 134 cases of colonic cancer in phase 1 malignant adenomas
were detected in 58% of patients. The rest of the patients were found to have
the co?called “minor” forms of cancer, like polyps, atrophic gastritis or
atrophic?hyper plastic gastritis. The endoscopic verification of GC and CC
with reference to the diacrisis of phases II, III and IV of the diseases com?
pletely confirmed the results of the NLS?investigation.
172 patients were found to have GC or CC discovered by NLS?examina?
tion conducted within a less than a year interval. Among them 62% of patients
13
Potentials of NLS method in diagnosing
gastric and calonic cancers
P.A. Svetlova, N.A. Sorokina,
T.G. Kuznetsova, V.I. Nesterova,
L.A. Yankina, N.V. Tatisohev
The non?linear diagnostics method (NLS) used in the Oberon device has
been actively practiced lately at many medical institutions. The most tangible
results were achieved by using the NLS method as a means of dispensary
observation. In the course of its development and advancement the method
has become a foremost tool of diagnostics and observation with respect to a
number of widespread digestive organs diseases; it allows to promptly collect
detailed information about a lesion and its pattern and assess the treatment
efficiency. That kind of diseases include gastrodoudenal ulcer, chronic gastri?
tis, and also benign and malignant gastric and colonic tumors. The specific
character and working conditions of the therapeutic and clinical institutions
in Russia allow to extensively employ the NLS method not only for diagnos?
ing diseases with some symptoms present but also for dispensary observation,
and what is more, practically all the patients in need of examination can be
placed under observation. So the physicians can now cover patients with the
changes that are latent and can only be verified by means of NLS. Specifically,
such patients include those having precancerous diseases or a mucous distur?
bance in the upper and/or lower sections of the digestive tract and patients
who developed a tumor, which still remains latent in a certain phase.
According to the data acquired by some medical specialists, using the
device for NLS?diagnostics, and based on annual research in thousands of
cases, the frequency of detecting focal or diffuse changes, typical for chronic
atrophic gastritis in patients over 50 years old, is within 30?40%. The analy?
sis of the spectral examinations of pattern?different sections of focal changes
in stomach mucosa shows that different symptoms of diseases including
intestinal metaplasia and epithelial dysplasia can be detected in them just as
often. During NLS analysis symptoms of gastric ulcer were recorded in about
5% of cases, polyps in stomach in 7% and polyps in colon in 45% of cases.
Thus, even the NLS analysis results alone, without other risk factors taken
into account, indicate that most of the patients in the respective age group
appear to be among those who need dynamic observation because of poten?
tial gastric cancer (GC) or colonic cancer (CC).
12
detection. The analysis of the available data allows to assume that tumor may
develop within a short time interval reaching the size of either “minor cancer”
or extensive lesion. All that confirms the idea that the tumor growth dynam?
ics in different patients and in different phases of the disease is likely to vary
and be of both continuous and discrete pattern. So a possible scenario of
tumor development could be the emergence of “early” gastric cancer against
the background of precancerous gastric diseases with a subsequent prolonged
period of existence in the initial phase which allows to diagnose it after a year
or a longer time later. At the same time, this “benign” scenario of disease
progress is not typical for some patients and because of the rapid tumor growth
we just fail to detect the initial phase of the condition in advance. The colonic
cancer development through the benign phase and then through a malignant
adenoma is not the only possible scenario it can proceed. Tumor can develop
de novo and here too, a variant of a comparatively slow or fast growth is poten?
tial. This provides an explanation for an “accidental” detection of patients with
fairly large tumors during dispensary observation and a great number of
patients with a short clinical anamnesis and late phases of the disease.
Thus, NLS can be considered as an adequate method for diagnosing gas?
tric and colonic cancers. The difficulties in dealing with NLS interpretation
largely concern the initial phases where the frequency of disease detection
depends in the long run on how keen the physicians are on performing a spec?
tral verification of any focal changes in the mucosa in the case of a chronic
gastritis and on keeping the patients under dynamic observation at the given
modes of elimination and NLS?analysis involved. The submitted results allow
to segregate two principal variants of the disease diagnosis. The first one sug?
gests “accidental” tumor detection during NLS?investigation; neither clinical
nor other familiar signs of disease are in evidence or their intensity is an insuf?
ficient reason for the patient to see a doctor. The second variant occurs when
the patients develop clinical implications which impell the physician to carry
out the respective investigations for them. The results of diacrisis of gastric and
colonic cancers indicate that for most patients the problem of early diagnosis
can not be solved, not only because of certain organizational factors but also
and primarily because of the specific pattern of the disease progress and its
manifestations. However, the actual opportunities for improving the well?
timed disease diagnosis in practical public health conditions lie, primarily, in
increasing the number of patients to be examined by means of the NLS?
method within the frameworks of a health survey and also in a timely and
complete examination of the patients who are suspected to have the disease.
15
had an initial phase of gastric cancer and 38% of the patients during previous
observation were found to have some or other signs of chronic gastritis in the
form of focal mucosa hyperplasia, local inflammation or wall deformation.
According to morphological investigation, the said sections were of a benign
nature and cancer developed therein over the last year only. In the rest of the
patients the macroscopic changes corresponding to malignant affection (spec?
tral similarity to “gastric carcinoma” reference standard D<0.425) occurred in
the span between the last two examinations. The preceding endoscopy detect?
ed atrophic gastritis free of focal changes in the area of the developed tumor.
Similar NLS data were acquired for 38 patients who during a year’s observation
were diagnosed to have developed a tumor corresponding to phases II and III.
The NLS of the colon and straight intestine was performed a year before
tumors were diagnosed in 21 patients affected by malignant polyps, of whom 17
had been under active observation because of polyposis, while no formation of
that kind was in evidence during the initial examination. In addition, within the
same time span 13 patients were examined who were diagnosed with a precan?
cerous condition (spectral similarity to straight intestine carcinoma, reference
standard D>0.7) and minor forms of cancer. In 6 of the patients the tumor
developed in the area of endoscopic polypectomy after they had a large villous
adenoma removed. Thus, in 34 (27%) of 121 patients, who were diagnosed to
have a malignant polyp condition in phase I or a small size tumor, colonic can?
cer developed within a year. 36 patients examined within the same time interval
were found to have the conditions in phase II and III just as frequently. 28 of
them were subjected to regular medical check?ups with no clinical signs of the
disease in evidence in any of them. 8 patients, within 3?7 months prior to tumor
diagnosis, began to show signs of growing anemia or progressing stool retention.
The dispensary observation data for these patients, with the NLS method
employed a year before the cancer was detected, had indicated no tumor .
There are two very essential factors known to be of paramount importance for
malignant disease diagnosis; they are the quality of clinical and diagnostic techniques
and the specific pattern of the disease progress which actually determine the dynam?
ics of the disease progression. Considering the capabilities and working conditions in
the therapeutic institutions, the presented data on gastric and colonic cancer diag?
noses may to a certain extent be regarded as optimum. It implies, that even if all the
patients were readily diagnosed with the disease during the dispensary observation
(actually it is a matter of 60%), the phase I condition could have been detected only
in 40% of them. The analysis of causes of the late diagnosis cases suggests that such
cases could be prevented by improving organizational and methodical work.
Furthermore, the focus should be placed on the specific features of the
disease progress which are of great, and possibly of vital importance for tumor
14
International Anticancer Association in 1997 (the 5th revision). Phase T1
was diagnosed in 13 patients (21%), phase T2 ? in 26 patients (43%), phase
T3 in 17 patients (28%) and phase T4 in 5 patients (8%).
According to a pathomorphological examination, metastases into
regional lymph nodes were detected in 11 of 61 cases.
All the patients underwent NLS?investigation and ultrasound colonoc?
sopy to diagnose and localize new growths, define their size, growth patterns
and approximate morphological characteristics, and also ultrasound scan?
ning of the abdominal cavity and small pelvis organs to assess the condition
of the organs adjacent to the colon and diagnose distant metastases.
The NLS?investigation used the Oberon?4011 device equipped with a
4.9 GHz nonlinear sensor manufactured by the Institute of Practical
Psychophysics (Russia) and Clinic Tech Inc. (USA). The endoscopic ultra?
sonography made use of the endoscopic ultrasonographic system UM?20
complete with the ultrasonic colonoscope CF?UM20 (Olympus, Japan). The
echographia of the abdominal cavity made use of the diagnostic unit SSD?
630 (Aloka, Japan) and Logiq?700 (General Electric, USA).
Discussion of results
We know from experience that every NLS?investigation should be pre?
ceded by diagnostic colonocsopy, which evaluates anatomic characteristics of
the colon and defines the number, localization and macroscopic characteris?
tics of the new growths, and by ultrasound scanning of the abdominal cavity
as well. A thorough transabdominal ultrasound scanning is required to assess
the condition of the organs adjacent to the colon and diagnose remote metas?
tases.
A comparison of the NLS results with those of pathomorphological
investigations was made in order to define the potentials of the NLS?method
in differential diagnostics of benign and malignant colonic new growths.
The results of the NLS?investigation coincided with the pathomorpho?
logical investigation in 87 of 91 cases. Most of the errors occured in diagnos?
ing colon adenomas. In 6 of 31 cases the patient was suspected of having can?
cer. The analysis of the observations noted that difficulties in diagnostics were
related to the deformation of intestinal wall layers due to the pressure of a
nodal villous tumor rather than to a genuine invasion. Two false?negative
results were obtained in the case of malignant adenoma and cancer diacrises.
Thus, the accuracy of the NLS method in differential diagnostics of
malignant and benign colon tumors amounted to 81.3% and sensitivity to
79.8%, while the specificity made 76.4%. The method of treatment to be
chosen for patients affected by colon cancer depends on the tumor process
17
New potentials of NLS ?method
in colonic neoplasm diagnostics
V.I. Nesterova, T.G. Kuznetsova,
V.I. Metlushko, N.L. Ogluzdina
Introduction
Colonoscopy is successfully used today to diagnose colon new growths.
Based on a number of indications endoscopic investigation allows to get reli?
able information about the colonic growth surface in order to correctly clas?
sify its pattern and take a sample for morphological identification. Yet,
colonocsopy does not give an idea of the kind of internal structure the new
growth has, nor does it allow to assess the depth of the invasion of the colon
wall by a malignant tumor, determine its proliferation to adjacent organs or
metastases to regional lymph nodes. Besides, colonocsopy does not provide
information about extra intestinal new growths unless they have already per?
meated the intestinal wall.
The NLS?investigation of the colon using a 4.9 GHz high frequency
nonlinear sensor can help clear up all of these issues.
The NLS?investigation allows to examine intestinal wall layers and the
adrectal cellular tissue.
This research aimed to define the potentials of the NLS?method in a
more specific diagnostics of straight?and segmented intestine tumors.
The matter and investigation methods
In order to achieve the set goal 87 patients were examined in whom 91
new growths were investigated by means of the NLS?method. The examinees
included 41 men and 46 women aged from 31 to 83 with most of them (82%)
aged 50 and over. All the patients affected by colon new growths were given
one or another kind of surgical treatment depending on the pattern, size and
localization of the growth. Among them in 23 cases endoscopic polypectomy
was performed, in 61 cases a resection was done on different parts of the
colon and in 3 patients transanal endomicrosurgery was performed. All of the
NLS?investigation results were verified by a pathomorphological examina?
tion of macro preparations according to which the colonic new growths were
represented by simple tumors in 30 cases and by glandular cancers with dif?
ferent degrees of differentiation in 61 cases. The stages of the malignant
process were defined according to TNM classification adopted by the
16
At this essay the greatest group were the tumours sized from 2 to 5 cm,
where the results proved to be lower, than in two first groups. The NLS data
and those of the pathomorphologic essays coincided in 66,7 % of cases. An
appreciable share of mistakes (60 %) occurred in phase Т2, where the intes?
tinal wall invasion depth was overestimated in all observations.
The great value has the fact, that according to pathomorphologic essay,
in 5 of 6 cases of hyperdiagnostics apart from the tumoral infiltration an
expressed inflammation was detected in deeper layers of the intestinal wall.
The relatively low accuracy of diagnosed depth of the intestinal wall invasion
by a tumour sized from 2 to 5 cm is due to the fact that 24 of 30 observations
of this group corresponded to phases Т2 and ТЗ. A differential diagnostics of
the tumoral infiltration depth in these phases is complex.
At the next research stage we made comparative analysis of the effect of
the form of growht of the neoplasm for accuracy of defining the phase of
tumoral invasion in the intestinal wall. All neopasms were classified into three
groups In function of the shape of the tumor growth: polypiform, saucer?
shaped and infiltrative.
The highest results were obtained when diagnosing the phase of the
saucer?shaped growth cancer process where the accuracy of defining the
tumoral invasion in the intestinal wall was 78.3 %.
It seems however impossible to fully estimate the accuracy of the NLS
method in defining the depth of a tumoral invasion at neoplasms with saucer?
shaped growth because of its dismall occurrence among other forms in
patients surveyed by us.
The polypiform of the growth was noted in 30 neoplasms. The growths
had a distinct interface with unaltered sections of the intestinal wall and did
not block the intestine lumen by more than half, which created favorable
conditions for the survey. The accuracy of NLS method in defining the depth
of tumoral invasion in the intestine wall was as high as 65 %. It has to be
noted, that half of all cases divergent with the pathomorphologic conclusions
is due to the overestimated depth of tumoral infiltration at defining the phase
Т2, which is connected with the presence of a perifocal inflammation.
This fact suggests difficulties in defining the phase of a cancer process in
cases where the tumoral invasion is compounded by the inflammatory com?
ponent penetrating deeper layers of the intestinal wall and beyond its limits.
The neoplasms with an infiltrative growth shape have proved to be most
difficult in defining the degree of the tumoral invasion into the intestinal wall.
In this this group the results of NLS method and those of the pathomorpho?
logic essays coincided only in 49,8 % of observations. It was due to the fact
that these neoplasms, as a rule, had a large size and occupied more than a half
19
phase. A comparison was made to the pathomorphological investigation data
in 61 cases in order to assess the diagnostic effeciency of the NLS?method in
classifying the colonic cancer phase.
The correct definition of the phase of tumor process was possible in
68.4% of the observations. The best results were obtained in defining phases
T3 and T4, where the diagnostic accuracy was 78.2% and 81.2% respective?
ly. It should be noted that most of the errors occurred in determining phases
T1 and T2, where the data of NLS and pathomorphological investigations
coincided only in 54.2% and 47.4% of the observations respectively.
In diagnosing phase T1 mistakes were made in 4 cases with 3 of the
errors toward overstating the phase; in one case signs of intestinal wall inva?
sion were not found and the tumor was taken for adenoma. In the analysis of
phase T2 diagnostic errors in overstated phases were noted in 7 of 9 cases; an
understatement of phase of the tumor process occurred in one case and yet in
one case no evidence of invasion proved to be found. The analysis of the post
surgical morphological conclusions made it clear that in 6 of 7 false positive
results the pathomorphological investigation of a macro preparation detect?
ed a deeper infiltration into the intestinal wall. However, according to micro?
scopic examination, the infiltration was of inflammatory rather than of a
tumorous kind. It should also be noted that in all of the cases it had to do with
an infiltrative tumorous process in the inferior ampullar section of the
straight intestine free of serous membrane while the inflammatory infiltration
area was located in adrectal cellular tissue.
To find out the causes that present difficulties for diagnosis the efficien?
cy of the NLS?method was analysed in function of the size, localization and
form of germination of neoplasms. The best results were obtained in diag?
nosing new growths sized under 2 cm and over 5 cm.
The epithelial tumour over 5 cm in size is represented by phases ТЗ and
Т4 in 12 of 17 cases. It has to be noted, that at large neoplasms the data of
NLS essay did not coincide with pathomorphologic data only in phase Т2,
where the process phase was overestimated because of the presence of inflam?
matory infiltration in deeper layers, than the layers where the tumoral inva?
sion occured. Thus, at neoplasms larger than 5 cm in size the diagnostics of
the invasion degree of the intestinal wall is feasible in 78.2 % of observations.
High results were also obtained at the estimation of depth of tumoral inva?
sion by neoplasms sized up to 2 cm. Most of them are represented by a
tumour in phases Т1 and Т2. The results of ultrasonic colonoscopy have
coincided with those of pathomorphologic conclusions in 76.7 % of the
observations. It should also be noted, that tumours sized up to 2 cm are most
convenient for examination since they have the least number of artefacts.
18
3. The diagnostic efficiency of NLS method in defining the phase of
tumoral process in the rectum is lower, than in segmented intestine.
4. The diagnostical accuracy of the cancer phase in colon depends as
much on the size as on the anatomic shape of the tumour growth. The best
results were obtained at defining depth of invasion of the intestinal walls by a
tumour sized under 2 cm and over 5 cm.
21
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